We consider the task of representation learning for unsupervised segmentation of 3D voxel-grid biomedical images.

Neural enhancement through super-resolution (SR) deep neural networks (DNNs) opens up new possibilities for ultra-high-definition (UHD) live streaming over existing encoding and networking infrastructure. Yet, the heavy SR DNN inference overhead leads to severe deployment challenges. To reduce the overhead, existing systems propose to apply DNN-based SR only on carefully selected anchor frames while upscaling non-anchor frames via the lightweight reusing-based SR approach. However, frame-level scheduling is coarse-grained and fails to deliver optimal efficiency. In this work, we propose Palantir, the first neural-enhanced UHD live streaming system with fine-grained patch-level scheduling. Two novel techniques are incorporated into Palantir to select the most beneficial anchor patches and support latency-sensitive UHD live streaming applications. Firstly, under the guidance of our pioneering and theoretical analysis, Palantir constructs a directed acyclic graph (DAG) for lightweight yet accurate SR quality estimation under any possible anchor patch set. Secondly, to further optimize the scheduling latency, Palantir improves parallelizability by refactoring the computation subprocedure of the estimation process into a sparse matrix-matrix multiplication operation. The evaluation results suggest that Palantir incurs a negligible scheduling latency accounting for less than 5.7% of the end-to-end latency requirement. When compared to the naive method of applying DNN-based SR on all the frames, Palantir can reduce the SR DNN inference overhead by 20 times (or 60 times) while preserving 54.0-82.6% (or 32.8-64.0%) of the quality gain. When compared to the state-of-the-art real-time frame-level scheduling strategy, Palantir can reduce the SR DNN inference overhead by 80.1% at most (and 38.4% on average) without sacrificing the video quality.

H&E-to-IHC stain translation techniques offer a promising solution for precise cancer diagnosis, especially in low-resource regions where there is a shortage of health professionals and limited access to expensive equipment. Considering the pixel-level misalignment of H&E-IHC image pairs, current research explores the pathological consistency between patches from the same positions of the image pair. However, most of them overemphasize the correspondence between domains or patches, overlooking the side information provided by the non-corresponding objects. In this paper, we propose a Mix-Domain Contrastive Learning (MDCL) method to leverage the supervision information in unpaired H&E-to-IHC stain translation. Specifically, the proposed MDCL method aggregates the inter-domain and intra-domain pathology information by estimating the correlation between the anchor patch and all the patches from the matching images, encouraging the network to learn additional contrastive knowledge from mixed domains. With the mix-domain pathology information aggregation, MDCL enhances the pathological consistency between the corresponding patches and the component discrepancy of the patches from the different positions of the generated IHC image. Extensive experiments on two H&E-to-IHC stain translation datasets, namely MIST and BCI, demonstrate that the proposed method achieves state-of-the-art performance across multiple metrics.

Deep learning methods for graphs achieve remarkable performance on many node-level and graph-level prediction tasks. However, despite the proliferation of the methods and their success, prevailing Graph Neural Networks (GNNs) neglect subgraphs, rendering subgraph prediction tasks challenging to tackle in many impactful applications. Further, subgraph prediction tasks present several unique challenges: subgraphs can have non-trivial internal topology, but also carry a notion of position and external connectivity information relative to the underlying graph in which they exist. Here, we introduce SubGNN, a subgraph neural network to learn disentangled subgraph representations. We propose a novel subgraph routing mechanism that propagates neural messages between the subgraph's components and randomly sampled anchor patches from the underlying graph, yielding highly accurate subgraph representations. SubGNN specifies three channels, each designed to capture a distinct aspect of subgraph topology, and we provide empirical evidence that the channels encode their intended properties. We design a series of new synthetic and real-world subgraph datasets. Empirical results for subgraph classification on eight datasets show that SubGNN achieves considerable performance gains, outperforming strong baseline methods, including node-level and graph-level GNNs, by 19.8% over the strongest baseline. SubGNN performs exceptionally well on challenging biomedical datasets where subgraphs have complex topology and even comprise multiple disconnected components.